SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 17-CHLORO-16(17) UNSATURATED D-HOMO ANTIPROGESTINS

Authors
SCHWEDE W CLEVE A NEEF G OTTOW E STOCKEMANN K WIECHERT R
Citation
W. Schwede et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 17-CHLORO-16(17) UNSATURATED D-HOMO ANTIPROGESTINS, Steroids, 59(3), 1994, pp. 176-180
Citations number
15
Categorie Soggetti
Biology,"Endocrynology & Metabolism
Journal title
Steroids → ACNP
ISSN journal
0039128X
Volume
59
Issue
3
Year of publication
1994
Pages
176 - 180
Database
ISI
SICI code
0039-128X(1994)59:3<176:SABO1U>2.0.ZU;2-7
Abstract
An efficient approach to 17-chloro-16(17) unsaturated D-homo antiproge stins is described. The key steps of the synthesis are a ring-expansio n via dichlorocarbene addition to a 17-silyl enol ether and a palladiu m catalyzed coupling of an 11 beta-(4-aryltriflate) with tributyl(1-et hoxyethenyl)stannane or diethyl(3-pyridinyl)borane. The new progestelo ne antagonists were tested for their biological activities and compare d to those of known antiprogestins.