SEX-RELATED PHARMACOKINETIC AND PHARMACODYNAMIC VARIATIONS OF LISINOPRIL

The aim of the present study was to determine whether or not the pharm acokinetic and hemodynamic response to a 20 mg single oral dose of lis inopril was sex-dependent. Thirty-two young healthy volunteers (16 mal es and 16 females) were included in the;trial. Blood samples to assess lisinopril plasma concentrations, determined indirectly by inhibition of the angiotensin converting enzyme (ACE) nod hemodynamic variables were obtained before and at different times following drug intake. No significant differences in pharmacokinetic parameters were observed be tween males and females. An hypotensive response was obtained between 2 nod 10 h for systolic blood pressure and between 2 and 24 h for dias tolic blood pressure. Again, no significant sex-related differences we re noted. Lisinopril was well tolerated.