EFFECTS OF LOW PH ON HEMAGGLUTINATING AND HEMOLYTIC ACTIVITIES OF WEST EQUINE ENCEPHALOMYELITIS VIRUS

Authors
VILLELA MT COUCEIRO JNSS CABRAL MC
Citation
Mt. Villela et al., EFFECTS OF LOW PH ON HEMAGGLUTINATING AND HEMOLYTIC ACTIVITIES OF WEST EQUINE ENCEPHALOMYELITIS VIRUS, Brazilian journal of medical and biological research, 27(3), 1994, pp. 613-621
Citations number
28
Categorie Soggetti
Medicine, Research & Experimental
Journal title
Brazilian journal of medical and biological research → ACNP
ISSN journal
0100879X
Volume
27
Issue
3
Year of publication
1994
Pages
613 - 621
Database
ISI
SICI code
0100-879X(1994)27:3<613:EOLPOH>2.0.ZU;2-7
Abstract
1. The hemagglutinating (HA) and hemolytic (HL) activities mediated by egg-propagated west equine encephalomyelitis (WEE) virus preparations were investigated. 2. The purified virus preparation exhibited the be st HA and HL activity at pH 6.0 and 6.0-6.2, respectively, as observed in the HA and HL tests. 3. In the virus preparations, both HA and HL activities were completely lost upon pretreatment at low pH (6.0). 4. The present results suggest that the alphavirus-mediated HA and HL act ivities against chicken erythrocytes can be considered to be a fusion ''from without''.