LYMPHOCYTIC HYPOPHYSITIS CAUSING HYPOPITUITARISM AND DIABETES-INSIPIDUS, AND ASSOCIATED WITH AUTOIMMUNE-THYROIDITIS, IN A NONPREGNANT WOMAN

A 25 year old non-pregnant woman presented with a one-year history of amenorrhoea and polyuria. Three months before her admission, she had s uffered lymphocytic meningitis. Hormonal studies revealed hypopituitar ism and central diabetes insipidus, with associated primary autoimmune hypothyroidism. Computed tomographic scan and magnetic resonance imag ing showed a pituitary mass with suprasellar extension and thickened s talk. Transsphenoidal surgery was performed and the histological study revealed fibrosis and diffuse lymphocytic infiltration with predomina nce of CD4 lymphocytes. This further case of lymphocytic hypophysitis was not related to pregnancy and produced diabetes insipidus, two unco mmon associations. We discuss the features that can lead to a preopera tive suspicion of this rare disorder.