FUNCTIONALIZED CALIXSPHERANDS - SYNTHESIS AND PEPTIDE COUPLING

Calixspherands, like 1, form kinetically stable complexes with alkali metal cations. For practical in vivo applications coupling of these co mplexes with carrier molecules is mandatory, Therefore, a general meth od for the synthesis of functionalized calixspherand 17 was developed starting from functionalized m-terphenyl 10 and p-tert-butylcalix[4]ar ene (14). The functionalized m-terphenyl was synthesized by a Suzuki-c ross-coupling reaction. Functionalized calixspherand 17 has been coupl ed to a low molecular weight protein.