ESTIMATION OF TC-99(M)-MAG3 CLEARANCE USING A SINGLE BLOOD-SAMPLE OBTAINED OVER A CONTINUOUS-TIME INTERVAL

Simplified methods based on a single blood sample have been proposed t o estimate the clearance of I-131- hippuran (HIP) and Tc-99(m)-mercapt oacetyltriglycine (MAG). The blood sample is usually drawn at that tim e which yields a minimum error between the estimated clearance and tha t obtained by the standard nine-sample method. In this paper, we estab lish the regression equations to obtain the HIP and MAG clearances usi ng one sample withdrawn during a fixed time interval. As HIP has long been the agent of choice, we have also established regression equation s to estimate the clearance of HIP using one sample after MAG administ ration. Our results suggest that it is possible to obtain plasma sampl es 30-50 min post-injection which result in an error of the estimate o nly slightly higher than the minimum.