IN-VITRO RELEASE OF [H-3] 5-HYDROXYTRYPTAMINE FROM FETAL AND MATERNALBRAIN BY DRUGS OF ABUSE

Authors
KRAMER K AZMITIA EC WHITAKERAZMITIA PM
Citation
K. Kramer et al., IN-VITRO RELEASE OF [H-3] 5-HYDROXYTRYPTAMINE FROM FETAL AND MATERNALBRAIN BY DRUGS OF ABUSE, Developmental brain research, 78(1), 1994, pp. 142-146
Citations number
23
Categorie Soggetti
Neurosciences
Journal title
Developmental brain research → ACNP
ISSN journal
01653806
Volume
78
Issue
1
Year of publication
1994
Pages
142 - 146
Database
ISI
SICI code
0165-3806(1994)78:1<142:IRO[5F>2.0.ZU;2-A
Abstract
Cortical synaptosomes were prepared from pregnant dams (GD-17) and rat fetuses (ED-17), loaded with [H-3]5-HT and assayed to evaluate releas e mediated by cocaine (CO C), fenfluramine (FEN) and 3,4-methylenediox ymethamphetamine (MDMA). COC and FEN elicited a high-affinity (10(-9) M) release response in fetal tissue which was not apparent in the dam. MDMA-induced release was similar in magnitude in both tissue types. C onsequently, the release of 5-HT from developing neurons may be one me chanism by which COC and FEN elicit their teratogenetic effects in ute ro.