S. Romangoldstein et al., OSMOTIC BLOOD-BRAIN-BARRIER DISRUPTION - CT AND RADIONUCLIDE IMAGING, American journal of neuroradiology, 15(3), 1994, pp. 581-590
Citations number
34
Categorie Soggetti
Neurosciences,"Radiology,Nuclear Medicine & Medical Imaging
PURPOSE: To compare CT and radionuclide imaging of osmotic blood-brain
barrier disruption. To develop a quantitative method for imaging osmo
tic blood-brain barrier disruption and to see if iopamidol could be sa
fely given intravenously in conjunction with blood-brain barrier disru
ption. METHODS: Forty-five blood-brain barrier disruption procedures w
ere imaged with CT and radionuclide scans. The scans were evaluated wi
th visual and quantitative scales. Patients were observed for adverse
effects after blood-brain barrier disruption. RESULTS: There was a 4%
rate of seizures in this study. There was good agreement between visua
l CT and radionuclide grading systems. Quantitative methods to grade d
isruption did not add useful information to visual interpretations. CO
NCLUSIONS: Nonionic iodine-based contrast medium has a lower incidence
of seizures when injected intravenously in conjunction with osmotic b
lood-brain barrier disruption than ionic contrast material. Contrast-e
nhanced CT is the preferred method to image disruption because it has
better spatial resolution than radionuclide techniques.