COMBINING 2-POINT GENETIC-LINKAGE ANALYSES USING MAPPING FUNCTIONS

Citation
Dj. Schaid et Rc. Elston, COMBINING 2-POINT GENETIC-LINKAGE ANALYSES USING MAPPING FUNCTIONS, Genetic epidemiology, 11(1), 1994, pp. 1-17
Citations number
13
Categorie Soggetti
Genetics & Heredity","Public, Environmental & Occupation Heath
Journal title
ISSN journal
07410395
Volume
11
Issue
1
Year of publication
1994
Pages
1 - 17
Database
ISI
SICI code
0741-0395(1994)11:1<1:C2GAUM>2.0.ZU;2-9
Abstract
A likelihood ratio statistic is proposed for combining two-point genet ic linkage analyses when the two-point analyses are between a trait an d a well-defined map of markers. It is assumed that the two-point anal yses are independent, as in the case of choosing only the most informa tive marker per family. The asymptotic distribution of the likelihood ratio statistic is derived under the null hypothesis of no linkage of the trait with a map of 2 markers, with intermarker genetic distance D elta. This distribution is shown to be a chi-square mixture distributi on with mixing probability depending on Delta and the assumed mapping function. We use this asymptotic result to approximate the distributio n of the likelihood ratio statistic for the more general case of more than 2 markers. Simulation results indicate that this may be reasonabl e. Power is evaluated by simulations and results indicate that this ap proach, which constrains the intermarker distances to their known valu es, tends to be more powerful than other methods proposed in the liter ature. (C) 1994 Wiley-Liss,Inc.