Y. Kajimoto et al., IDENTIFICATION OF AMINO-ACID POLYMORPHISM WITHIN THE LEUCINE-ZIPPER MOTIF OF MOUSE TRANSCRIPTION FACTOR A1, Gene, 139(2), 1994, pp. 247-249
Mouse transcription factor A1 (A1) is a mouse homologue of human E47,
a ubiquitously expressed DNA-binding protein which contains a basic re
gion, helix-loop-helix (HLH) and leucine zipper (LZ) motifs [Walker et
al., Nucleic Acids Res. 18 (1990) 1159-1166]. Analyses of the nucleot
ide (nt) sequences of A1 cDNAs isolated from various mouse strains rev
ealed amino acid (aa) polymorphism in the highly conserved region with
in the LZ motif. Interestingly, the location and pattern of aa deletio
ns are identical to those previously described for the aa polymorphism
within the human counterpart, E47 (E12) [Kamps et al., Cell 60 (1990)
547-555].