Objective: Our goal was to determine the appearance and enhancement pa
ttern of human pineal glands on MRI. Materials and Methods: High-resol
ution sagittal MR images (3 mm section thickness with an 18 cm field o
f view) obtained in 60 patients were retrospectively analyzed to deter
mine the size and enhancement patterns of normal pineal glands followi
ng the intravenous injection of contrast medium. Results: Pineal gland
s were either solid (40%) or cystic (60%) with various enhancement pat
terns: diffuse (15%) and partially enhanced (25%) in solid and ring-li
ke (20%) and peripherally partial (40%) in cystic. Their diameter exce
eded 10 mm but was <20 mm in five cases and resembled cystic pineal ne
oplasms. Two such cases were found to be histologically normal. Conclu
sion: Information on the appearance and enhancement patterns of normal
pineal glands on MR images can improve the accuracy of diagnosing spa
ce-occupying lesions in the pineal region and perhaps help to prevent
unnecessary surgery.