AN UMPOLUNG ROUTE TO PEPTIDE MIMETICS OF THYROTROPIN-RELEASING-HORMONE BASED ON A CYCLOHEXANE FRAMEWORK

Authors
BOS M OLSON GL VINCENT GP
Citation
M. Bos et al., AN UMPOLUNG ROUTE TO PEPTIDE MIMETICS OF THYROTROPIN-RELEASING-HORMONE BASED ON A CYCLOHEXANE FRAMEWORK, Helvetica Chimica Acta, 77(2), 1994, pp. 463-469
Citations number
11
Categorie Soggetti
Chemistry
Journal title
Helvetica Chimica Acta → ACNP
ISSN journal
0018019X
Volume
77
Issue
2
Year of publication
1994
Pages
463 - 469
Database
ISI
SICI code
0018-019X(1994)77:2<463:AURTPM>2.0.ZU;2-E
Abstract
Peptide mimetics of thyrotropin-releasing hormone (TRH) in which the p eptide backbone is replaced by cyclohexane were synthesized from the c yclohexenone precursor 7. The aromatic side chains of the mimetics wer e derived from the corresponding aldehydes which were attached to the cyclohexenone via the Wittig reagent 8. The TRH mimetics are active in a mouse model of cognitive performance.