M. Bos et al., AN UMPOLUNG ROUTE TO PEPTIDE MIMETICS OF THYROTROPIN-RELEASING-HORMONE BASED ON A CYCLOHEXANE FRAMEWORK, Helvetica Chimica Acta, 77(2), 1994, pp. 463-469
Peptide mimetics of thyrotropin-releasing hormone (TRH) in which the p
eptide backbone is replaced by cyclohexane were synthesized from the c
yclohexenone precursor 7. The aromatic side chains of the mimetics wer
e derived from the corresponding aldehydes which were attached to the
cyclohexenone via the Wittig reagent 8. The TRH mimetics are active in
a mouse model of cognitive performance.