CARBAMATE SERIES OF JUVENOIDS - VARIATION OF THE O-ALKYL SUBSTITUENT

By changing the O-alkyl substituents of the carbamate moiety of alkyl [(2-oxocyclohexyl)-methyl]phenoxy}ethyl}carbamates and subsequent tran sformation of the oxo group in the cyclohexyl substituent, the juvenoi ds 1-20 were synthesized (Scheme). The methyl (1-4), propyl (9-12), is opropyl (13-16), and prop-2-ynylcarbamates (17-20) were subjected to b iological screening on several non-related insect species (Tenebrio mo litor, Galleria mellonella, Dysdercus cingulatus, and Pyrrhocoris apte rus). Some of the juvenoids showed high biological activity and excell ent selectivity with respect to target insect species (Table 2).