USE OF EXOGENOUS HORMONES AND RISK OF TEMPOROMANDIBULAR DISORDER PAIN

Temporomandibular disorders (TMD) are common pain conditions that have their highest prevalence among women of reproductive age. The higher prevalence of TMD pain among women, pattern of onset after puberty and lowered prevalence rates in the postmenopausal years suggest that fem ale reproductive hormones may play an etiologic role in TMD. Two epide miologic studies were designed to assess whether use of exogenous horm ones is associated with increased risk of TMD pain. Both used data fro m automated pharmacy records of women enrolled in a large health maint enance organization to identify prescriptions filled for post-menopaus al hormone replacement therapies (Study 1) or for oral contraceptives (OCs) (Study 2). Study 1 employed an age-matched case-control design t o compare post-menopausal hormone use among 1291 women over age 40 ref erred for TMD treatment and 5164 controls not referred. After controll ing for health services use, the odds of being a TMD case were approxi mately 30% higher among those receiving estrogen compared to those not exposed (P = 0.002); a clear dose-response relationship was evident. The relationship of progestin use to TMD was not statistically signifi cant. Study 2 used a similar design to examine the relationship of OC use to referral for TMD care, drawing on data from 1473 cases and 5892 controls aged 15-35. Use of OCs was also associated with referral for TMD care, with an increased risk of TMD of approximately 20% for OC u sers, after controlling for health services use (P < 0.05). These resu lts suggest that female reproductive hormones may play an etiologic ro le in orofacial pain. This relationship warrants further investigation through epidemiologic, clinical and basic research.