Periodontal diseases may be the first clinical sign of human immunodef
iciency virus (HIV)-infection. Since the immunosuppression and subsequ
ent susceptibility may alter the responses of the oral tissues as well
as the microflora, both periodontal treatment and result of therapy m
ay be modified. The periodontal diseases in HIV-seropositive patients
include common as well as less conventional forms of gingivitis and pe
riodontitis, and bacterial, mycotic and viral infections are seen. Neo
plasias may also involve the periodontium; most common are Kaposi's sa
rcoma and non-Hodgkin's lymphoma. Recent studies of unselected groups
of patients indicate that periodontal health in at least some groups o
f HIV-seropositive patients is better than previously reported.