AMLODIPINE-INDUCED GINGIVAL OVERGROWTH

Amlodipine is a calcium channel blocker used in the management of angi na and hypertension. We report 3 cases of gingival overgrowth in adult dentate patients associated with chronic usage of this drug. Gingival changes occurred within 3 months of dosage and appeared to be compoun ded by the patient's existing periodontal condition. In all 3 patients , there was sequestration of amlodipine in their crevicular fluid. The significance of this finding in relation to the pathogenesis of this unwanted effect remains to be elucidated.