CELL-KINETICS OF HEAD AND NECK SQUAMOUS-CELL CARCINOMAS - PROGNOSTIC IMPLICATIONS

Authors
NYLANDER K ANNEROTH G GUSTAFSSON H ROOS G STENLING R ZACKRISSON B
Citation
K. Nylander et al., CELL-KINETICS OF HEAD AND NECK SQUAMOUS-CELL CARCINOMAS - PROGNOSTIC IMPLICATIONS, Acta oncologica, 33(1), 1994, pp. 23-28
Citations number
26
Categorie Soggetti
Oncology
Journal title
Acta oncologica → ACNP
ISSN journal
0284186X
Volume
33
Issue
1
Year of publication
1994
Pages
23 - 28
Database
ISI
SICI code
0284-186X(1994)33:1<23:COHANS>2.0.ZU;2-5
Abstract
Forty-three squamous cell carcinomas of the head and neck region were in vivo labelled with the thymidine analogue iododeoxyuridine. Combine d flow cytometric (FCM) and immunohistochemical (IHC) analysis was per formed, and the following parameters calculated: labelling index (LI), S-phase time (T(S)) and potential tumor doubling time (T(pot)). Compl ete FCM and IHC analyses could successfully be performed in 31 cases, showing a median LI of 13.6% with FCM and 9.1% with IHC. A correlation achieved between LI/FCM and LI/IHC was due to the aneuploid cases, wh ereas the diploid cases showed no such correlation. Data indicated tha t T(pot) calculated with LI from IHC (T(pot)/IHC) might be a prognosti c factor, in contrast to T(pot) determined using LI/FCM.