BIPHASIC EFFECTS OF INTRAACCUMBENS MU-OPIOID PEPTIDE AGONIST DAMGO ONLOCOMOTOR ACTIVITIES

Authors
MEYER ME MCLAURIN BI ALLEN M MEYER ME
Citation
Me. Meyer et al., BIPHASIC EFFECTS OF INTRAACCUMBENS MU-OPIOID PEPTIDE AGONIST DAMGO ONLOCOMOTOR ACTIVITIES, Pharmacology, biochemistry and behavior, 47(4), 1994, pp. 827-831
Citations number
39
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Pharmacology, biochemistry and behavior → ACNP
ISSN journal
00913057
Volume
47
Issue
4
Year of publication
1994
Pages
827 - 831
Database
ISI
SICI code
0091-3057(1994)47:4<827:BEOIMP>2.0.ZU;2-Y
Abstract
The effects of bilateral microinjections of mu-opioid receptor agonist DAMGO (0.00, 0.01, 0.1, or 1.0 mu g/side) were tested in rats for 120 min in activity monitors. The horizontal movement, rearing, and stere otypy times in seconds were measured during 12 consecutive 10-min time blocks. DAMGO (0.01, 0.1, and 1.0 mu g) resulted in biphasic effects, inhibition followed by activation for each of the three measures. The se data replicate the behavioral effects of ICV DAMGO except that the duration of the behavioral effects were longer with Acb injections.