FOOD-DEPRIVATION AND MOTOR-ACTIVITY IN RATS - DIFFERENCES BETWEEN MORPHINE AND CLONIDINE

Authors
BARTOLETTI M GAIARDI M GUBELLINI C BACCHI A BABBINI M
Citation
M. Bartoletti et al., FOOD-DEPRIVATION AND MOTOR-ACTIVITY IN RATS - DIFFERENCES BETWEEN MORPHINE AND CLONIDINE, Pharmacology, biochemistry and behavior, 47(4), 1994, pp. 969-972
Citations number
20
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Pharmacology, biochemistry and behavior → ACNP
ISSN journal
00913057
Volume
47
Issue
4
Year of publication
1994
Pages
969 - 972
Database
ISI
SICI code
0091-3057(1994)47:4<969:FAMIR->2.0.ZU;2-S
Abstract
The effects of various doses of morphine (0, 1.25, 2.5, 5 mg/kg) and c lonidine (0, 1.67, 15, 45 mu g/kg) on motility were determined in food satiated and in food deprived rats. Food deprivation failed to change the general activity of rats after saline injections. Nevertheless, f ood-deprived animals tested under morphine were more active than food satiated ones. Clonidine exhibited slight psychomotor stimulant proper ties that were not increased by food deprivation. The results are disc ussed in terms of possible mechanisms of deprivation-related hypermoti lity.