SMALL VIRUS-LIKE STRUCTURE IN FRACTIONS FROM SCRAPIE HAMSTER BRAIN

Authors
OZEL M DIRINGER H
Citation
M. Ozel et H. Diringer, SMALL VIRUS-LIKE STRUCTURE IN FRACTIONS FROM SCRAPIE HAMSTER BRAIN, Lancet, 343(8902), 1994, pp. 894-895
Citations number
8
Categorie Soggetti
Medicine, General & Internal
Journal title
Lancet → ACNP
ISSN journal
01406736
Volume
343
Issue
8902
Year of publication
1994
Pages
894 - 895
Database
ISI
SICI code
0140-6736(1994)343:8902<894:SVSIFF>2.0.ZU;2-F
Abstract
The scrapie model in hamsters has been used to search for the agents t hat cause Creutzfeldt-Jakob disease in man and similar transmissible e ncephalopathies in animals. We found structures that are extraordinari ly small for a virus, but exhibit viral structural properties in negat ively stained samples, by electron microscopy in fractions containing scrapie-associated fibrils.