HUMAN CYTOMEGALOVIRUS REPLICATION CORRELATES WITH DIFFERENTIATION IN A HEMATOPOIETIC PROGENITOR-CELL LINE AND CAN BE MODULATED BY HIV-1

Human cytomegalovirus (HCMV) infection of a CD34+ hematopoietic progen itor cell line (TF1) was studied before and after TPA differentiation. TF1 cells were found to be infected but the virus does not replicate, while differentiated TF1 cells can be infected and allow HCMV complet e replication. In the same system we studied the interaction between H CMV and HIV and found that while contact between HIV gp 120 and the HC MV-infected cell has an inhibitory effect, exogenous Tat protein stimu lates HCMV replication. The interaction between HCMV and HIV in hemato poietic progenitor cells is complex and depends on several factors tha t can have opposite effects.