One aspect of tissue engineering of skeletal muscle involves the trans
position and transplantation of whole muscles to treat muscles damaged
by injury or disease. The transposition of whole muscles has been use
d for many decades, but since 1970, the development of techniques for
microneurovascular repair has allowed the transplantation of large mus
cles. Transposition and transplantation of muscles invariably result i
n structural and functional deficits. The deficits are of the greatest
magnitude during the first month, and then a gradual recovery results
in the stabilization of structural and functional variables between 9
0 and 120 days. In stabilized vascularized grafts ranging from 1 to 3
g in rats to 90 g in dogs, the major deficits are similar to 25% decre
ase in muscle mass and in most grafts similar to 40% decrease in maxim
um force. The decrease in power is more complex because it depends on
both the average shortening force and the velocity of shortening. As a
consequence, the deficit in maximum power may be either greater or le
ss than the deficit in maximum force. Tenotomy and repair are the majo
r factors responsible for the deficits. Although the data are limited,
skeletal muscle grafts appear to respond to training stimuli in a man
ner no different from that of control muscles. The training stimuli in
clude traditional methods of endurance and strength training, as well
as chronic electrical stimulation. Transposed and transplanted muscles
develop sufficient force and power to function effectively to: mainta
in posture; move limbs; sustain the patency of sphincters; partially r
estore symmetry in the face; or serve as, or drive, assist devices in
parallel or in series with the heart. (C) 1994 John Wiley and Sons, In
c.