REACTION OF 5-AMINOPYRAZOLE DERIVATIVES WITH ETHOXYMETHYLENE-MALONONITRILE AND ITS ANALOGS

Authors
NAGAHARA K KAWANO H SASAOKA S UKAWA C HIRAMA T TAKADA A COTTAM HB ROBINS RK
Citation
K. Nagahara et al., REACTION OF 5-AMINOPYRAZOLE DERIVATIVES WITH ETHOXYMETHYLENE-MALONONITRILE AND ITS ANALOGS, Journal of heterocyclic chemistry, 31(1), 1994, pp. 239-243
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
31
Issue
1
Year of publication
1994
Pages
239 - 243
Database
ISI
SICI code
0022-152X(1994)31:1<239:RO5DWE>2.0.ZU;2-9
Abstract
A one-pot synthesis using 5-aminopyrazole derivatives 1 with ethoxymet hylenemalononitrile (EMMN), ethyl ethoxymethylenecyanoacetate (EMCA) o r diethyl ethoxymethylenemalonate (DEMM) gave pyrazolo-[1,5-a]pyrimidi ne compounds 2,4,8. Also, the one step reaction of EMCA with hydrazine hydrate afforded oxycarbonyl-5-pyrazolyl)aminomethylenecyanoacetate 3 c. On the other hand, the reaction of 1-substituted 5-aminopyrazole-4- carboxamide 9 with EMMN afforded pyrazolo[3,4-d]pyrimidine compounds 1 0.