PHOSPHATE-ACTIVATED GLUTAMINASE EXPRESSION DURING TUMOR-DEVELOPMENT

Citation
Jc. Aledo et al., PHOSPHATE-ACTIVATED GLUTAMINASE EXPRESSION DURING TUMOR-DEVELOPMENT, FEBS letters, 341(1), 1994, pp. 39-42
Citations number
26
Categorie Soggetti
Biophysics,Biology
Journal title
ISSN journal
00145793
Volume
341
Issue
1
Year of publication
1994
Pages
39 - 42
Database
ISI
SICI code
0014-5793(1994)341:1<39:PGEDT>2.0.ZU;2-O
Abstract
Changes in phosphate-activated glutaminase activities determined in in tact cells and isolated mitochondria have been followed during mouse E hrlich ascites carcinoma development. Glutaminase activities parallel the levels of poly(A)(+) RNAs encoding for the mitochondrial phosphate activated glutaminase. During the exponential growth phase, maximum a ctivity was observed and the relative abundance of glutaminase mRNA si gnificantly increased with regard to the stationary growth phase. The presented results show that tumor phosphate-activated glutaminase is s ubject to long-term regulation by differential gene expression.