Records of coma and post-traumatic amnesia (PTA) were collected for a
group of 38 patients with closed head injury. The results confirmed ea
rlier studies indicating that patients may have short or negligible co
ma but report prolonged PTA. Comparison of eight patients with prolong
ed PTA (>7 days) and short coma (<6 hours) with the rest of the group
on MRI in the acute stage showed that these patients had significantly
more extensive hemispheric damage. In the group as a whole both coma
and PTA were related to the number of areas in central brain structure
s in which lesions were detected, but only PTA was significantly relat
ed to the number of hemispheric areas in which lesions were found. It
is concluded that although both coma and PTA are related to brain dama
ge they reflect disparate patterns of lesions. Assessment of PTA can t
hus provide additional information concerning severity of injury.