Pa. Tresco, ENCAPSULATED CELLS FOR SUSTAINED NEUROTRANSMITTER DELIVERY TO THE CENTRAL-NERVOUS-SYSTEM, Journal of controlled release, 28(1-3), 1994, pp. 253-258
Recent studies evaluating the therapeutic usefulness of an implantable
, bioartificial prosthesis for treating Central Nervous System (CNS) d
isorders are reviewed. A description of the implant along with advanta
ges over conventional technology is presented. Experimental evidence f
rom in vitro and in vivo experiments suggests the potential usefulness
of this approach in the treatment of such CNS disorders as Parkinson'
s disease and chronic pain that may be treated by the sustained releas
e of one or more neuroactive agents in a specific location.