DRUG TRANSPORT TO THE BRAIN - IN-VITRO VERSUS IN-VIVO APPROACHES

Authors
DEBOER AG DEVRIES HE DELANGE ECM DANHOF M KUIPER J BREIMER DD
Citation
Ag. Deboer et al., DRUG TRANSPORT TO THE BRAIN - IN-VITRO VERSUS IN-VIVO APPROACHES, Journal of controlled release, 28(1-3), 1994, pp. 259-263
Citations number
23
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Journal of controlled release → ACNP
ISSN journal
01683659
Volume
28
Issue
1-3
Year of publication
1994
Pages
259 - 263
Database
ISI
SICI code
0168-3659(1994)28:1-3<259:DTTTB->2.0.ZU;2-C
Abstract
This paper summarizes the applicability of in vitro and in vivo method s to assess drug transport to the brain. In vitro methods: culture of confluent monolayers of bovine brain endothelial cells which represent the blood-brain barrier (BBB) and confocal laser scanning microscopy. In vivo methods: BBB-clearance model and microdialysis in rats. Ascer taining selectivity in BBB-transport in disease states is emphasized.