During construction of an ileocecal reservoir, such as the Mainz or In
diana pouch, the ileocecal valve is lost. Subsequently, the intestinal
transit time is shortened and malabsorption as well as diarrhea may r
esult. Patients having undergone previous bowel resection as well as c
hildren with myelomeningocele who often already have frequent defecati
ons will be heavily affected by the loss of the ileocecal valve. We ha
ve functionally reconstructed the ileocecal valve by embedding ileum i
nto the ascending colon via a submucosal tunnel in analogy to the tech
nique used when creating the continence mechanism during the Mainz pou
ch procedure using the appendix. Experimental results in 15 dogs demon
strated that the surgically reconstructed valve genuinely mimics the p
hysiological function of the authentic valve and confirmed a marked tr
ansit time prolongation without evidence of obstruction. Our first cli
nical experience in 12 patients using this operative technique is prom
ising. Equally, the morphological appearance of the newly created valv
e closely resembles the genuine ileocecal valve during barium enema as
well as endoscopic investigations.