RESPONSE OF METASTASIZED SEX CORD GONADAL STROMAL TUMOR OF THE TESTISTO CISPLATIN-BASED CHEMOTHERAPY

A 34-year-old man underwent left hemicastration for malignant unclassi fied sex cord gonadal stromal tumor. At 6 months pulmonary metastases developed and the patient received 3 courses of chemotherapy consistin g of cisplatin, bleomycin and etoposide. A residual focus in the right lung was excised and proved to be viable tumor. He then received 2 ad juvant courses of cisplatin, etoposide and ifosfamide. Six months late r he was without evidence of disease. A review of the literature revea led 21 previous cases of malignant unclassified sex cord gonadal strom al tumor. Although chemotherapy usually fails in treating Leydig cell tumors our case corroborates 6 previous reports of favorable response to cisplatin-based chemotherapy. This finding suggests that different subtypes of sex cord gonadal stromal tumor respond differently to chem otherapy.