BIOSYNTHESIS OF WITHANOLIDES IN ACNISTUS-BREVIFLORUS - INCORPORATION OF LABELED 24-METHYLENECHOLESTEROL

Authors
MONTEAGUDO ES BURTON G GROS EG
Citation
Es. Monteagudo et al., BIOSYNTHESIS OF WITHANOLIDES IN ACNISTUS-BREVIFLORUS - INCORPORATION OF LABELED 24-METHYLENECHOLESTEROL, Phytochemistry, 35(4), 1994, pp. 927-929
Citations number
11
Categorie Soggetti
Plant Sciences
Journal title
Phytochemistry → ACNP
ISSN journal
00319422
Volume
35
Issue
4
Year of publication
1994
Pages
927 - 929
Database
ISI
SICI code
0031-9422(1994)35:4<927:BOWIA->2.0.ZU;2-E
Abstract
Feeding experiments with [24-C-14] 24-methylenecholesterol and mixture s of this sterol and [7-H-3] 24-methylenecholesterol were performed to study the biosynthesis of withanolides in the plant Acnistus breviflo rus. The results indicate that the side chain of the sterol precursor should be broken between C-24 and C-25 to give an intermediate which f ollows the biogenetic pathway into withaferin A, jaborosalactone A and jaborosalactone D.