HIV-INHIBITORY NATURAL-PRODUCTS .11. COMPARATIVE-STUDIES OF SULFATED STEROLS FROM MARINE-INVERTEBRATES

Authors
MCKEE TC CARDELLINA JH RICCIO R DAURIA MV IORIZZI M MINALE L MORAN RA GULAKOWSKI RJ MCMAHON JB BUCKHEIT RW SNADER KM BOYD MR
Citation
Tc. Mckee et al., HIV-INHIBITORY NATURAL-PRODUCTS .11. COMPARATIVE-STUDIES OF SULFATED STEROLS FROM MARINE-INVERTEBRATES, Journal of medicinal chemistry, 37(6), 1994, pp. 793-797
Citations number
28
Categorie Soggetti
Chemistry Medicinal
Journal title
Journal of medicinal chemistry → ACNP
ISSN journal
00222623
Volume
37
Issue
6
Year of publication
1994
Pages
793 - 797
Database
ISI
SICI code
0022-2623(1994)37:6<793:HN.COS>2.0.ZU;2-W
Abstract
A total of 22 sulfated sterols isolated from marine sponges, ophiuroid s (brittle stars), and asteroids (sea stars) were comparatively evalua ted for their antiviral activity against HIV-1 and HIV-2. In general, sterols with sulfate groups at position 2, 3, or 6 were the most activ e, with EC50 values- of 3-13 muM against HIV-1 (RF) and 2-8 muM agains t HIV-2 (CBL20). Those compounds which were sulfated on the sterol D r ing were completely inactive against both HIV-1 and HIV-2. Overall, su lfated sterols active against HIV-1 were also active against HIV-2.