OBJECTIVE - To determine the extent of functional impairment among vet
erans with diabetes and investigate whether such functional impairment
is associated with measures of glycemic control, sensory neuropathy,
lower extremity macrovascular disease, or other comorbid conditions. R
ESEARCH DESIGN AND METHODS - A 20-item general health survey (SF-20) d
eveloped by the Medical Outcomes Study (MOS) Group, was administered t
o 577 subjects participating in a prospective study of risk factors fo
r diabetic foot ulceration. Measures of glycemic control and neurovasc
ular disease included GHb, sensory lower extremity neuropathy assessed
by aesthesiometry, and segmental lower extremity doppler blood pressu
res. RESULTS - Veterans with diabetes have major decreases in all doma
ins of functional status; 87% were in poor health in terms of physical
functioning and 86% in terms of health perceptions. Those with advanc
ing age, symptoms of neuropathy and claudication, and a medical histor
y of complications associated with diabetes had significantly more imp
airment of health status than those without. GHb values did not correl
ate with functional status measures. Subjects with neuropathy had stat
istically significant functional impairment. Subjects with vasculopath
y had only two significantly low health status measures. CONCLUSIONS -
in summary, the findings from this survey reveal that veterans with d
iabetes have low functional status scores. The presence of symptoms an
d complications accounts for only part of the impairments experienced
by this group.