UREA-SENSOR FOR THE CONTINUOUS AMMONIUM-S ELECTIVE-ENZYMATIC PROCESS-CONTROL OF THE ARTIFICIAL-KIDNEY

Authors
SCHINDLER JG SCHINDLER MM HERNA K REISINGER E BURK B KUHLMANN U KNAACK J SCHMIDT B LANGE H
Citation
Jg. Schindler et al., UREA-SENSOR FOR THE CONTINUOUS AMMONIUM-S ELECTIVE-ENZYMATIC PROCESS-CONTROL OF THE ARTIFICIAL-KIDNEY, European journal of clinical chemistry and clinical biochemistry, 32(3), 1994, pp. 145-152
Citations number
38
Categorie Soggetti
Biology,"Chemistry Medicinal
Journal title
European journal of clinical chemistry and clinical biochemistry → ACNP
ISSN journal
09394974
Volume
32
Issue
3
Year of publication
1994
Pages
145 - 152
Database
ISI
SICI code
0939-4974(1994)32:3<145:UFTCAE>2.0.ZU;2-M
Abstract
Presented is a flow-through method for continuous ammonium-selective e nzymatic monitoring of the artificial kidney by means of a bioelectroc hemical urea electrode. The urea is converted in an enzyme membrane by covalently bound urease and the ammonium ions are detected by a Nonac tin-PVC-membrane. In addition to detailed data from the oxygen-indepen dent solid-state contact sensor, curves are obtained on-line from the patient during the haemodialysis session. The advantages of the method are described in detail. Furthermore, the urea sensor can be used for measurements in heparinized blood.