G. Liapiavgeri et al., GLOMUS TUMOR - A HISTOLOGICA, HISTOCHEMICAL AND IMMUNOHISTOCHEMICAL STUDY OF THE VARIOUS TYPES, Pathology research and practice, 190(1), 1994, pp. 2-10
Glomus tumors are benign lesions composed of vessels and glomocytes in
varying proportions. The histological appearance of the tumors depend
upon the ratio of the vascular to the glomus cells and their differen
tiation as well as upon the amount and composition of the stroma. The
aim of the present study was the establishment of criteria for the dis
tinction of glomus tumor-like malformations from neoplasms with glomus
cell differentiation. Using a panel of monoclonal and polyclonal anti
bodies (vimentin, a-smooth muscle actin, desmin, pan-keratin, low mole
cular weight cytokeratin, EMA, NSE, S-1 00 protein, Factor VIII, a1-AC
T) glomus tumors could be separated into three types: vascular, cellul
ar with myxoid stroma and cellular, solid type. In the first two types
the tumor growth is composed of all three components found in normal
glomus body, but in a haphazard fashion and thus might be considered a
s tumor-like malformations. The third type is composed of perivascular
arranged cells most of which acquire the phenotypical characteristics
of glomocytes. This last tumor probably represent the neoplastic vari
ant of the group of lesions designated by the term glomus tumor.