5-SUBSTITUTED 4-ISOXAZOLEACETIC ACIDS WITH ANALGESIC ACTIVITY

Authors
FOSSA P MENOZZI G SCHENONE P MATTIOLI F
Citation
P. Fossa et al., 5-SUBSTITUTED 4-ISOXAZOLEACETIC ACIDS WITH ANALGESIC ACTIVITY, Il Farmaco, 49(1), 1994, pp. 41-44
Citations number
9
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Il Farmaco → ACNP
ISSN journal
0014827X
Volume
49
Issue
1
Year of publication
1994
Pages
41 - 44
Database
ISI
SICI code
0014-827X(1994)49:1<41:54AWAA>2.0.ZU;2-G
Abstract
The synthesis of some 5-substituted 4-isoxazoleacetic acids starting f rom 5-substituted 4-isoxazolemethanols via their conversion to 4-(brom omethyl)isoxazoles, 4-isoxazoleacetonitriles and acid hydrolysis of th e latter is described. 5-Ethyl- and 5-propyl-4-isoxazoleacetic acids s howed in the writhing test an analgesic activity comparable to that of aspirin.