PERMEATION OF OENANTHE-AQUATICA FRUIT TINCTURE BETA-CYCLODEXTRIN COMPLEX THROUGH ARTIFICIAL MEMBRANES

The complexation of Oenanthe aquatica fruit tincture with beta-cyclode xtrin leads to its stabilization against ageing. An increase in its bi oavailability may also be expected. To support this hypothesis, an in vitro study, according to Stricker, both of the tincture itself and as tincture/beta-cyclodextrin complex was performed. It was observed tha t the amount of complexed tincture passing through an artificial membr ane is about three times higher than that of the tincture itself. Incr eased permeation of the complexed form may be attributed to the compon ents acquiring greater hydrosolubility and higher dissolution rate, he nce increasing the amount of products in solution which are available for permeation. Moreover, it was observed that the complexed form also guarantees greater homogeneity in the passage of the various componen ts through the artificial membrane in comparison to the tincture itsel f.