Gr. Lauretti et al., THE ACTIVITY OF OPIOID ANALGESICS IN SEIZURE MODELS UTILIZING N-METHYL-DL-ASPARTIC ACID, KAINIC ACID, BICUCULLINE AND PENTYLENETETRAZOLE, Neuropharmacology, 33(2), 1994, pp. 155-160
Morphine, fentanyl and pethidine exhibited a biphasic dose response re
lationship with respect to their effects on seizure thresholds to bicu
culline, pentylenetetrazole, N-methyl-DL-aspartate (NMDLA) and kainic
acid in mice. The usual pattern was for low doses to be anticonvulsant
and higher doses to be proconvulsant. However this pattern was revers
ed for fentanyl and pethidine when NMDLA was used to induce seizures.
The low dose effects of all three opioid drugs was sensitive to 1 mg k
g(-1) naloxone in all seizure models. The responses to high doses of p
ethidine were unaffected or enhanced by this dose of naloxone. Naloxon
e reversed the effects of the higher doses of morphine and fentanyl in
all models except bicuculline induced seizures.