OMEGA-CONOTOXIN MVIIC REVERSIBLY INHIBITS A HUMAN N-TYPE CALCIUM-CHANNEL AND CALCIUM INFLUX INTO CHICK SYNAPTOSOMES

Authors
GRANTHAM CJ BOWMAN D BATH CP BELL DC BLEAKMAN D
Citation
Cj. Grantham et al., OMEGA-CONOTOXIN MVIIC REVERSIBLY INHIBITS A HUMAN N-TYPE CALCIUM-CHANNEL AND CALCIUM INFLUX INTO CHICK SYNAPTOSOMES, Neuropharmacology, 33(2), 1994, pp. 255-258
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Neurosciences
Journal title
Neuropharmacology → ACNP
ISSN journal
00283908
Volume
33
Issue
2
Year of publication
1994
Pages
255 - 258
Database
ISI
SICI code
0028-3908(1994)33:2<255:OMRIAH>2.0.ZU;2-T
Abstract
We have investigated the effects of omega-CmTX MVIIC on the recombinan t alpha(1B)-mediated calcium channel expressed in HEK 293 cells and on the predominantly N-type calcium channel in chick synaptosomes. omega -CmTX MVIIC potently and reversibly inhibited the calcium current thro ugh alpha(1B)-mediated calcium channels and inhibited KCl-evoked incre ases in [Ca2+](i) in chick synaptosomes in a concentration-dependent m anner.