ENANTIOSELECTIVE INHIBITION OF APOMORPHINE-INDUCED EMESIS IN THE FERRET BY THE NEUROKININ(1) RECEPTOR ANTAGONIST CP-99,994

Citation
Fd. Tattersall et al., ENANTIOSELECTIVE INHIBITION OF APOMORPHINE-INDUCED EMESIS IN THE FERRET BY THE NEUROKININ(1) RECEPTOR ANTAGONIST CP-99,994, Neuropharmacology, 33(2), 1994, pp. 259-260
Citations number
10
Categorie Soggetti
Pharmacology & Pharmacy",Neurosciences
Journal title
ISSN journal
00283908
Volume
33
Issue
2
Year of publication
1994
Pages
259 - 260
Database
ISI
SICI code
0028-3908(1994)33:2<259:EIOAEI>2.0.ZU;2-U
Abstract
These studies have examined the effects of the selective neurokinin, ( NK1) receptor antagonist CP-99,994 on the retching and vomiting respon se to apomorphine. CP-99,994 (1-3 mg/kg i.p.) attenuated retching and vomiting induced by apomorphine (0.25 mg/kg s.c.) with complete inhibi tion of retching and vomiting at the 3 mg/kg dose. In contrast CP-100, 263 (3 mg/kg i.p.), the enantiomer of CP-99,994 with 1000-fold lower a ffinity for the NK1 receptor, was without effect.