Fd. Tattersall et al., ENANTIOSELECTIVE INHIBITION OF APOMORPHINE-INDUCED EMESIS IN THE FERRET BY THE NEUROKININ(1) RECEPTOR ANTAGONIST CP-99,994, Neuropharmacology, 33(2), 1994, pp. 259-260
These studies have examined the effects of the selective neurokinin, (
NK1) receptor antagonist CP-99,994 on the retching and vomiting respon
se to apomorphine. CP-99,994 (1-3 mg/kg i.p.) attenuated retching and
vomiting induced by apomorphine (0.25 mg/kg s.c.) with complete inhibi
tion of retching and vomiting at the 3 mg/kg dose. In contrast CP-100,
263 (3 mg/kg i.p.), the enantiomer of CP-99,994 with 1000-fold lower a
ffinity for the NK1 receptor, was without effect.