CLINICAL AND HISTOLOGICAL FEATURES OF MECHANICS HANDS IN A PATIENT WITH ANTIBODIES TO JO-1 - A CASE-REPORT

Authors
MITRA D LOVELL CL MACLEOD TIF TAN RSH MADDISON PJ
Citation
D. Mitra et al., CLINICAL AND HISTOLOGICAL FEATURES OF MECHANICS HANDS IN A PATIENT WITH ANTIBODIES TO JO-1 - A CASE-REPORT, Clinical and experimental dermatology, 19(2), 1994, pp. 146-148
Citations number
4
Categorie Soggetti
Dermatology & Venereal Diseases
Journal title
Clinical and experimental dermatology → ACNP
ISSN journal
03076938
Volume
19
Issue
2
Year of publication
1994
Pages
146 - 148
Database
ISI
SICI code
0307-6938(1994)19:2<146:CAHFOM>2.0.ZU;2-B
Abstract
The clinical and histological features of 'mechanic's hands' are descr ibed in a patient with polymyositis characterized serologically by ant ibodies to histidyl tRNA synthetase (Jo-1). Although described in the past in association with polymyositis, these distinctive cutaneous les ions have only recently been associated with the 'anti-synthetase synd rome'. It is becoming apparent that recognition of subsets within the spectrum of polymyositis/dermatomyositis characterized by certain clin ical and serological features not only have prognostic significance, b ut also may provide insights into mechanisms of disease.