Ad. Pemberton et al., INVESTIGATION OF ASSOCIATION BETWEEN ALPHA-1 PROTEINASE-INHIBITOR HAPLOTYPE AND ENDOMETRITIS IN THE THOROUGHBRED MARE, Equine veterinary journal, 26(2), 1994, pp. 122-124
Failure to inhibit proteinases can lead to excessive tissue damage. Th
e possibility that the severity of endometritis in Thoroughbred mares
correlates with the haplotypes of plasma alpha1-proteinase inhibitor (
alpha1-PI) expressed was investigated in two groups of mares. In mares
with pyometritis before treatment, the frequency of the N haplotype,
which is already high in the Thoroughbred population, was significantl
y increased when compared with that in a large published population. I
n mares with acute endometritis which persisted after treatment follow
ed by sexual rest, the absence of S and T haplotypes was significant,
suggesting that, when present, they may have a protective function.