IDENTIFICATION AND SEMI-QUANTIFICATION OF ESTROGEN AND PROGESTERONE RECEPTORS IN PERIPHERAL GIANT-CELL LESIONS OF THE JAWS

CASES OF PERIPHERAL GIANT CELL LESIONS Of the jaws (PGCL) were evaluat ed for the detection of estrogen and progesterone receptor proteins (E RS/PRS) utilizing immunoperoxidase staining. Staining for ERS was stro ngly positive in three cases when examining the mononuclear cell popul ation. Another two cases were weakly positive. In addition, an occasio nal ER+ multinucleated giant cell could be observed in three of the ca ses examined. PRS immunoreactivity was essentially negative in all cas es. It is well known that the PGCL has a marked female predilection. T his, coupled with the present findings, gives further evidence that so me PGCL may be at least partially under hormonal influence.