THE EFFECT OF HETEROATOM SUBSTITUTION ON A SERIES OF PHOSPHONATE INHIBITORS OF NEUTRAL ENDOPEPTIDASE-24.11

Authors
STANTON JL KSANDER GM DEJESUS R SPERBECK DM
Citation
Jl. Stanton et al., THE EFFECT OF HETEROATOM SUBSTITUTION ON A SERIES OF PHOSPHONATE INHIBITORS OF NEUTRAL ENDOPEPTIDASE-24.11, Bioorganic & medicinal chemistry letters, 4(4), 1994, pp. 539-542
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
4
Year of publication
1994
Pages
539 - 542
Database
ISI
SICI code
0960-894X(1994)4:4<539:TEOHSO>2.0.ZU;2-Q
Abstract
A series of phosphonic acids, 7a-d, with heteroatom and carbon variati ons in the template backbone were prepared and tested for inhibition o f neutral endopeptidase 24.11. The structure-activity relationship of these derivatives is presented and discussed.