BENZOXEPIN AND BENZOTHIEPIN DERIVATIVES AS POTENT, ORALLY-ACTIVE INHIBITORS OF 5-LIPOXYGENASE

Authors
SATOH Y LIBBY AH POWERS C KOWALSKI TJ WHITE DH KIMBLE EF
Citation
Y. Satoh et al., BENZOXEPIN AND BENZOTHIEPIN DERIVATIVES AS POTENT, ORALLY-ACTIVE INHIBITORS OF 5-LIPOXYGENASE, Bioorganic & medicinal chemistry letters, 4(4), 1994, pp. 549-552
Citations number
21
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
4
Year of publication
1994
Pages
549 - 552
Database
ISI
SICI code
0960-894X(1994)4:4<549:BABDAP>2.0.ZU;2-J
Abstract
A series of N-hydroxyurea derivatives based on substituted benzoxepin and benzothiepin templates was prepared and the compounds were evaluat ed for their ability to inhibit 5-lipoxygenase in vitro and ex vivo.