1,2,5,6-TETRAHYDROPYRIDINE OXIME ETHERS INCORPORATING ELECTRON-WITHDRAWING GROUPS ARE POTENT AND SELECTIVE MUSCARINIC AGONISTS

Authors
BROMIDGE SM BROWN F CASSIDY F CLARK MSG COLLINGS EJ DABBS S FAULKNER RE LOUDON JM ORLEK BS RILEY GJ
Citation
Sm. Bromidge et al., 1,2,5,6-TETRAHYDROPYRIDINE OXIME ETHERS INCORPORATING ELECTRON-WITHDRAWING GROUPS ARE POTENT AND SELECTIVE MUSCARINIC AGONISTS, Bioorganic & medicinal chemistry letters, 4(4), 1994, pp. 557-562
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
4
Year of publication
1994
Pages
557 - 562
Database
ISI
SICI code
0960-894X(1994)4:4<557:1OEIE>2.0.ZU;2-1
Abstract
The combination of N-methoxy imidoyl halide and nitrile moieties with the 1,2,5,6-tetrahydropyridine ring system afforded a novel series of potent muscarinic agonists. Members of this class, exemplified by the imidoyl nitriles 2c and 3c, show favourable central selectivity. The i ncorporation of fluoroacetyl oxime ethers gave compounds with weak aff inity for muscarinic receptors.