CP-71,362, AN UNUSUALLY POTENT INHIBITOR OF RAT AND DOG RENIN

Authors
KLEINMAN EF FRAY AH HOLT WF KIRON MAR MURPHY WR PURCELL IM ROSATI RL
Citation
Ef. Kleinman et al., CP-71,362, AN UNUSUALLY POTENT INHIBITOR OF RAT AND DOG RENIN, Bioorganic & medicinal chemistry letters, 4(4), 1994, pp. 589-592
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
4
Year of publication
1994
Pages
589 - 592
Database
ISI
SICI code
0960-894X(1994)4:4<589:CAUPIO>2.0.ZU;2-K
Abstract
CP-71,362 (Boc-Phe-His-hexahydroPhe[OH]Leu-Lys-Phe) has been identifie d as the most potent inhibitor of rat plasma renin (IC50 = 3 nM) and d og plasma renin (IC50 = 3 pM) to date and thus can be used as an impor tant experimental tool in the study of the renin angiotensin system in these established hypertensive models.