NUCLEOSIDES AND NUCLEOTIDES .129. NEW NEPLANOCIN ANALOGS .3. 6'R-CONFIGURATION IS ESSENTIAL FOR THE ANTIVIRAL ACTIVITY OF 6'-C-METHYL-3-DEAZANEPLANOCIN AS

Authors
SHUTO S OBARA T KOSUGI Y SAITO Y TORIYA M YAGINUMA S SHIGETA S MATSUDA A
Citation
S. Shuto et al., NUCLEOSIDES AND NUCLEOTIDES .129. NEW NEPLANOCIN ANALOGS .3. 6'R-CONFIGURATION IS ESSENTIAL FOR THE ANTIVIRAL ACTIVITY OF 6'-C-METHYL-3-DEAZANEPLANOCIN AS, Bioorganic & medicinal chemistry letters, 4(4), 1994, pp. 605-608
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
4
Issue
4
Year of publication
1994
Pages
605 - 608
Database
ISI
SICI code
0960-894X(1994)4:4<605:NAN.NN>2.0.ZU;2-8
Abstract
(6'R)- and (6'S)-6'-C-methyl-3-deazaneplanocin A's were synthesized fr om D-ribose as anti-RNA virus agents. Of these compounds, (6'R)-6'-C-m ethyl-3-deazaneplanocin A (4b) showed the greatest anti-RNA virus acti vity in vitro. It was found that the 6'R-configuration was essential f or the antiviral activity of 6'-C-methylneplanocin A derivatives.