APOLIPOPROTEIN(A) PHENOTYPES IN CARDIOCEREBROVASCULAR DISEASES

We report apolipoprotein(a) (apo(a)) phenotypes of 69 myocardial infar ction survivors and 56 stroke patients, and compare them with those of 190 healthy Chinese. The results indicate that the distribution of ap o(a) phenotype frequency in cardio-cerebrovascular disease patients is different from those of controls. The frequency of the phenotypes B, S-1 and S-2 in patients is remarkably higher than those in controls wi thin the same single-band apo(a) phenotype. Moreover, the Lp(a) serum concentrations in CCVD patients are significantly higher than those in controls within the same single-band apo(a) phenotype. The apo(a) phe notype analyses of two pedigrees are shown as a typical autosomal domi nant inheritance.