EFFECTS OF ESTRADIOL ADMINISTRATION VIA DIFFERENT ROUTES ON THE LIPIDPROFILE IN WOMEN WITH BILATERAL OOPHORECTOMY

To determine the influence of various oestrogenenic administrations on lipid response, 63 women with total abdominal hysterectomy and bilate ral anexectomy were studied before and 6 and 12 months after receiving 17 beta-oestradiol by different means. The effect on the levels of li pids and lipoproteins of the 2 mg/24 h administration of oestradiol va lerate was compared with 1.5 mg/day of percutaneous 17 beta-oestradiol and 0.05 mg/day of transdermic oestradiol. The treatments were given continuously over a year. The oestradiol valerate produced a statistic ally significant increase (P < 0.05) of the HDL-C levels both after 6 and 12 months (10.6% vs. 11.6%). A significant increase was also obser ved (P < 0.05) in the Apo At levels during the treatment(l8 and 25%). On the other hand, unfavorable side effects with oestradiol were not p roduced, either percutaneous or transdermic, on lipid plasmatic or lip oprotein levels. These data show the benefit of oral oestrogenic thera py and the maintenance of the lipid profile in percutaneous and transd ermic therapies in oophorectomized women.