REGIONAL MAPPING OF LOCI FROM HUMAN-CHROMOSOME 2Q TO SHEEP CHROMOSOME2Q

The human chromosome 2q loci, fibronectin 1 (FN1), the alpha 1 chain o f type III collagen (COL3A1), and the delta subunit of the muscle acet ylcholine receptor (CHRND) have been regionally assigned to sheep chro mosome 2q by in situ hybridization. COL3A1 is pericentromeric (2q12-q2 1), while FN1 and CHRND are in the subterminal region at 2q41-q44 and 2q42-qter, respectively. The mapping of FN1 assigns the sheep syntenic group U11, which contains FN1, villin 1 (VIL1), isocitrate dehydrogen ase 1 (IDH1), and gamma subunit of the muscle acetylcholine receptor ( CHRNG), to sheep chromosome 2q. Inhibin-alpha (INHA) is also assigned to sheep chromosome 2q as FN1 and INHA compose sheep linkage group 3. These seven loci are members of a conserved chromosomal segment in hum an, mouse, and sheep. (C) 1994 Academic Press, Inc.